Lyrica (Pregabalin)
Lyrica is an anticonvulsant and antiepileptic medication. The active ingredient in the medicine is pregabalin, which prevents the passage of calcium into neurons’ cells in response to prospective action. The chemical has a high affinity for alpha-2-delta protein, which is found in central nervous system tissues.
When neurons are activated, the medication reduces the release of pain chemicals in the synaptic slit. As a result of such alterations caused by the drug’s effect, the impulse is selectively inhibited. However, Lyrica might only have such an impact under pathological situations.
The medicine is rapidly absorbed and begins to work within an hour after administration. The medicine is best administered on an empty stomach because the drug concentration in plasma is dramatically lowered when given with meals.
The medicine is withdrawn by the use of urine.
The dose of the medicine must be adjusted for the elderly and individuals with impaired renal function.
Indications for use
Lyrica is prescribed to treat fibromyalgia and neuropathic pain.
Furthermore, the medicine is utilized to treat people with anxiety problems and epileptic seizures. For the latter, the medication is approved for both long-term and short-term treatment of epilepsy and partial seizures.
Contraindications
Lyrica is contraindicated if you have an intolerance or allergy to any of the drug’s components.
Do not administer to children under the age of 12.
Pregnant and nursing women, as well as those with renal impairment, should be given extra care when the medication is prescribed.
Lactation and pregnancy There is little information on the use of Lyrica in pregnant women. As a result, prior to carefully weighing the risks and advantages of pharmaceutical therapy during pregnancy, competent medical supervision is suggested.
Women of reproductive age should use effective contraception to avoid conception.
Medication and breastfeeding are incompatible.
Method of reception
Lyrica pills should be swallowed whole. The tablets should not be crushed or eaten.
Lyrica can be taken with or without food, however it works best on an empty stomach.
The dose is determined by the attending physician based on the patient’s features, the type of the condition, and the progression of the disease.
For neuropathic pain and epilepsy, the typical suggested dosage is 75 mg twice daily. If necessary, the dose can be raised to 150 mg twice a day.
If the patient is hypersensitive to the drug’s activity or has a severe illness, the initial dosage is 150 mg, which is later increased least a week should elapse between dosage increases. The highest daily dosage is 600 mg.
The length of therapy is determined by the success of the treatment. You should not discontinue the medication abruptly; instead, gradually lower the dosage to zero.
Patients with renal system dosage issues are given doses based on their creatinine clearance level. The lower the ml/min ratio, the lower the initial and daily dosages.
To decide the dose, elderly persons should have their kidneys checked. The dose is the same as for others in the normal condition.
Overdose
Cases of drug overdose are not described. In an extreme case, it is possible to increase the side effects.
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